References: Drugs associated with the development of takotsubo

Drugs associated with the development of takotsubo

Cardiotonic drugs

1 Redfors, B., Ali, A., Shao, Y., Lundgren, J., Gan, L.M. and Omerovic, E., 2014. Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner. International Journal of Cardiology174(2), pp.330-336.

2Kido, K. and Guglin, M., 2017. Drug-induced takotsubo cardiomyopathy. Journal of Cardiovascular Pharmacology and Therapeutics22(6), pp.552-563.
3Nazir, S., Lohani, S., Tachamo, N., Ghimire, S., Poudel, D.R. and Donato, A., 2017. Takotsubo cardiomyopathy associated with epinephrine use: a systematic review and meta-analysis. International Journal of Cardiology229, pp.67-70.
4Y-Hassan, Shams 2017. Serotonin norepinephrine re-uptake inhibitor (SNRI)-, selective norepinephrine reuptake inhibitor (S-NRI)-, and exogenously administered norepinephrine-induced takotsubo syndrome: Analysis of published cases. International journal of cardiology231, pp.228-233.
5Fyfe, A.I., Daly, P.A., Dorian, P. and Tough, J., 1991. Reversible “cardiomyopathy” after accidental adrenaline overdose. The American journal of cardiology67(4), pp.318-319. DOI:10.1016/0002-9149(91)90570-B
6Budhwani, N., Bonaparte, K.L., Cuyjet, A.B. and Saric, M., 2004. Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. Reviews in cardiovascular medicine, pp.130-133.
7Meaudre, E., Barbou, F., Sallaberry, M., Cantais, E., Petit, D. and Palmier, B., 2004. Rapid reversal of global left ventricular dysfunction after accidental injection of 0.75 mg epinephrine in a 20‐year‐old patient. Acta anaesthesiologica scandinavica48(7), pp.914-916.
8Volz, H.C., Erbel, C., Berentelg, J., Katus, H.A. and Frey, N., 2009. Reversible left ventricular dysfunction resembling Takotsubo syndrome after self-injection of adrenaline. The Canadian Journal of Cardiology25(7), p.e261.
9Abraham, J., Mudd, J.O., Kapur, N., Klein, K., Champion, H.C. and Wittstein, I.S., 2009. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. Journal of the American College of Cardiology53(15), pp.1320-1325. doi:10.1016/j.jacc.2009.02.02
10Härle, T., Kronberg, K., Nef, H., Möllmann, H. and Elsässer, A., 2011. Inverted Takotsubo cardiomyopathy following accidental intravenous administration of epinephrine in a young woman. Clinical Research in Cardiology100(5), pp.471-473. 10.1007/s00392-010-0266-z
11Esnault, P., Née, L., Signouret, T., Jaussaud, N. and Kerbaul, F., 2014. Reverse Takotsubo cardiomyopathy after iatrogenic epinephrine injection requiring percutaneous extracorporeal membrane oxygenation. Canadian Journal of Anesthesia/Journal Canadien d’Anesthésie61(12), pp.1093-1097. 10.1007/s12630-014-0230-x
12Sherif, K., Sehli, S. and Jenkins, L.A., 2016, April. Takotsubo cardiomyopathy after administration of norepinephrine. In Baylor University Medical Center Proceedings (Vol. 29, No. 2, pp. 166-167). Taylor & Francis. 10.1080/08998280.2016.11929402
13Ouerghi, K., Boukhris, M., Grall, S., Desprets, L. and Quercy, M., 2016. Reverse iatrogenic Takotsubo syndrome after accidental bolus of norepinephrine in the setting of sepsis. Kardiologia Polska (Polish Heart Journal)74(8), pp.799-799.
14Subramaniam, A., Cooke, J.C. and Ernest, D., 2010. ‘Inverted’ Tako-Tsubo Cardiomyopathy Due to Exogenous Catecholamines. Critical Care and Resuscitation12(2), p.104.
15Keshtkar, F., Dale, O.T., Bennett, W.O. and Hall, C.E., 2016. Management of airway obstruction with nebulised adrenaline resulting in takotsubo cardiomyopathy: case report. The Journal of Laryngology & Otology130(9), pp.883-886.
16Zubrinich, C.M., Omar Farouque, H.M., Rochford, S.E. and Sutherland, M.F., 2008. Tako‐tsubo‐like cardiomyopathy after EpiPen administration. Internal
medicine journal
38(11), pp.862-865.
17Litvinov, I.V., Kotowycz, M.A. and Wassmann, S., 2009. Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the “broken heart syndrome”. Clinical research in cardiology98(7), pp.457-462. 10.1007/s00392-009-0028-y
18Manivannan, V., Li, J.T., Prasad, A. and Campbell, R.L., 2009, September. Apical ballooning syndrome after administration of intravenous epinephrine during an anaphylactic reaction. In Mayo Clinic Proceedings (Vol. 84, No. 9, p. 845). Mayo Foundation.
19Laínez, B., Ureña, M., Álvarez, V. and Lezaun, R., 2009. Iatrogenic Tako–Tsubo Cardiomyopathy Secondary to Catecholamine Administration. Revista espanola de cardiologia62(12), p.1498. DOI:10.1016/S1885-5857(09)73549-2
20Geppert, G., Radke, P.W., Kurowski, V., Hunold, P. and Schunkert, H., 2010. Wasp sting, adrenaline injection and acute thoracic pain: an un usual case of stress-induced (tako-tsubo) cardiomyopathy. Medizinische Klinik (Munich, Germany: 1983)105(4), pp.246-248. 10.1007/s00063-010-1032-8
21Morel, O., Jesel, L., Morel, N., Nguyen, A., Trinh, A., Ohlmann, P. and Imperiale, A., 2010. Transient left ventricular dysfunction syndrome during anaphylactic shock: vasospasm, Kounis syndrome or epinephrine-induced stunned myocardium?. International journal of cardiology145(3), pp.501-503.
22Dewachter, P., Tanase, C., Levesque, E., Nicaise-Roland, P., Chollet-Martin, S., Mouton-Faivre, C. and Benhamou, D., 2011. Apical ballooning syndrome following perioperative anaphylaxis is likely related to high doses of epinephrine. Journal of anesthesia25(2), pp.282-285.
23Magri, C.J., Fava, S. and Felice, H., 2011. Inverted takotsubo cardiomyopathy secondary to adrenaline injection. British Journal of Hospital Medicine72(11), pp.646-647.
24Scheiba, N., Viedt-Suelmann, C. and Schäkel, K., 2011. Tako-tsubo cardiomyopathy after a hymenoptera sting and treatment with catecholamines. Acta dermato-venereologica91(5), pp.593-594.
25Winogradow, J., Geppert, G., Reinhard, W., Resch, M., Radke, P.W. and Hengstenberg, C., 2011. Tako-tsubo cardiomyopathy after administration of intravenous epinephrine during an anaphylactic reaction. International Journal of Cardiology147(2), pp.309-311.
26Patankar, G.R., Donsky, M.S. and Schussler, J.M., 2012. Delayed takotsubo cardiomyopathy caused by excessive exogenous epinephrine administration after the treatment of angioedema. Proceedings (Baylor University. Medical Center)25(3), p.229.
27Kajander, O.A., Virtanen, M.P., Sclarovsky, S. and Nikus, K.C., 2013. Iatrogenic inverted takotsubo syndrome following intravenous adrenaline injections for an allergic reaction. International journal of cardiology165(1), pp.e3-e5.
28Khoueiry, G., Rafeh, N.A., Azab, B., Markman, E., Waked, A., AbouRjaili, G., Shariff, M. and Costantino, T., 2013. Reverse Takotsubo cardiomyopathy in the setting of anaphylaxis treated with high-dose intravenous epinephrine. The Journal of emergency medicine44(1), pp.96-99.
29Ghanim, D., Adler, Z., Qarawani, D., Kusniec, F., Amir, O. and Carasso, S., 2015. Takotsubo cardiomyopathy caused by epinephrine-treated bee sting anaphylaxis: a case report. Journal of medical case reports9(1), p.247.
30Surineni, K., Afzal, M.R., Barua, R. and Parashara, D., 2016. Epinephrine-Induced Takotsubo Cardiomyopathy. Federal Practitioner. October.
31Saeki, S., Matsuse, H., Nakata, H., Fukahori, S., Miyahara, Y. and Kohno, S., 2006. Case of bronchial asthma complicated with Takotsubo cardiomyopathy after frequent epinephrine medication. Nihon Kokyuki Gakkai zasshi= the journal of the Japanese Respiratory Society44(10), pp.701-705.
32Copetti, R., Gonano, C., Colombo, T. and Cattarossi, L., 2007. “Inverted Takotsubo” pattern. Resuscitation74(2), p.394. 10.1016/j.resuscitation.2007.04.009
33Redfors, Y. Shao, E. Omerovic Fatal stress-induced cardiomyopathy in a young patient treated with adrenomimetics Clin. Res. Cardiol., 101 (2012), pp. 939-940.
34Law, C., Khaliq, A. and Guglin, M., 2013. Reversible cardiogenic shock due to catecholamine-induced cardiomyopathy: a variant of takotsubo?. The American Journal of Emergency Medicine31(11), pp.1621-e1.
35Quick, S., Quick, C., Schneider, R., Sveric, K., Katzke, S., Strasser, R.H. and Ibrahim, K., 2013. Guillain–Barré syndrome and catecholamine therapy. A potential risk for developing takotsubo cardiomyopathy?. International journal of cardiology165(3), pp.e43-e44.
36Vieira A, Batista B, de Abreu T. 2018. Iatrogenic Takotsubo cardiomyopathy secondary to norepinephrine by continuous infusion for shock. European Journal of Case Reports in Internal Medicine5 doi:10.12890/2018_000894.
37Littlejohn, F.C., Syed, O., Ornstein, E., Connolly, E.S. and Heyer, E.J., 2008. Takotsubo cardiomyopathy associated with anesthesia: three case reports. Cases journal1(1), p.227.
38Tomcsányi, J., Arabadzisz, H., Frész, T., Sármán, B., Bózsik, B., Zsoldos, A. and Simor, T., 2008. Reverse Takotsubo syndrome pattern induced by local anaesthesia. Orvosi hetilap149(50), pp.2387-2389.
39Harika, R., Bermas, K., Hughes, C., Al-Khafaji, A., Iyer, M. and Wallace, D.J., 2014. Cardiac arrest after liver transplantation in a patient with takotsubo cardiomyopathy. British Journal of Anaesthesia112(3), pp.594-595.
40von Knobelsdorff-Brenkenhoff, F., Abdel-Aty, H. and Schulz-Menger, J., 2010. Takotsubo cardiomyopathy after nasal application of epinephrine—a magnetic resonance study. International journal of cardiology145(2), pp.308-309.
41Rodríguez, A., Freire, L., Cerizola, M., Olivera, M., Cordobez, J. and Trujillo, P., 2012. Síndrome de takotsubo durante la inducción de una anestesia general. Anestesia Analgesia Reanimación25(1), pp.13-18.
42Brunetti, N.D., Ferraretti, A., Scarcia, M., Sai, R., Ieva, R., Santoro, F., De Gennaro, L. and Di Biase, M., 2013. Ultra-fast Tako-Tsubo cardiomyopathy after local anesthesia for eye surgery: Are we missing the submerged bottom of the iceberg?. International journal of cardiology167(5), pp.e137-e139.
43Sundbøll, J., Pareek, M., Høgsbro, M. and Madsen, E.H., 2014. Iatrogenic takotsubo cardiomyopathy induced by locally applied epinephrine and cocaine. BMJ case reports2014, p.bcr2013202401.
44Imnadze, G., Metreveli, L., Franz, N. and Thale, J., 2014. Case of Takotsubo cardiomyopathy after tooth extraction–Unusual trigger of a rare syndrome.
Journal of cardiology cases10(4), pp.129-131.
45Gicquel-Schlemmer, B., Beller, J.P., Mchalwat, A. and Gicquel, P., 2015. Fatal Takotsubo cardiomyopathy due to epinephrine in shoulder arthroscopy. Orthopaedics & Traumatology: Surgery & Research101(8), pp.981-982.

Dobutamine and dopamine

46Brewington, S.D., Abbas, A.A., Dixon, S.R., Grines, C.L. and O’neill, W.W., 2006. Reproducible microvascular dysfunction with dobutamine infusion in Takotsubo cardiomyopathy presenting with ST segment elevation. Catheterization and cardiovascular interventions68(5), pp.769-774.
47Silberbauer, J., Hong, P. and Lloyd, G.W., 2007. Takotsubo cardiomyopathy (left ventricular ballooning syndrome) induced during dobutamine stress echocardiography. European Journal of Echocardiography9(1), pp.136-138.
48Cherian, J., Kothari, S., Angelis, D., Atef, A., Downey, B. and Kirkpatrick Jr, J., 2008. Atypical takotsubo cardiomyopathy: dobutamine-precipitated apical ballooning with left ventricular outflow tract obstruction. Texas Heart Institute Journal35(1), p.73.
49Kumar, A., Jenkins, L.A., Perez-Verdia, A. and Roongsritong, C., 2008. Transient left ventricular apical ballooning during dobutamine myocardial perfusion imaging. International journal of cardiology124(3), pp.378-380.
50Bruder, O., Hunold, P., Jochims, M., Waltering, K.U., Sabin, G.V. and Barkhausen, J., 2008. Reversible late gadolinium enhancement in a case of Takotsubo cardiomyopathy following high-dose dobutamine stress MRI. International journal of cardiology127(1), pp.e22-e24.
51Margey, R., Diamond, P., McCann, H. and Sugrue, D., 2008. Dobutamine stress echo-induced apical ballooning (Takotsubo) syndrome. European Journal of Echocardiography10(3), pp.395-399.
52Skolnick, A.H., Michelin, K., Nayar, A., Fisher, D. and Kronzon, I., 2009. Transient apical ballooning syndrome precipitated by dobutamine stress testing. Annals of internal medicine150(7), pp.501-502.
53Abraham, J., Mudd, J.O., Kapur, N., Klein, K., Champion, H.C. and Wittstein, I.S., 2009. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. Journal of the American College of Cardiology53(15), pp.1320-1325. doi:10.1016/j.jacc.2009.02.02
54Shah, B.N., Simpson, I.A. and Rakhit, D.J., 2010. Takotsubo (apical ballooning) syndrome in the recovery period following dobutamine stress echocardiography: a first report. European Journal of Echocardiography12(1), pp.E5-E5.
55Chaparro-Muñoz, M., Recio-Mayoral, A., Kaski, J.C., Brecker, S. and Sutherland, G.R., 2010. Myocardial stunning identified by using strain/strain rate imaging during dobutamine stress echocardiography in a rare late recurrence of Tako–Tsubo syndrome. International journal of cardiology145(1), pp.e9-e12.
56Mosley II, W.J., Manuchehry, A., McEvoy, C. and Rigolin, V., 2010. Takotsubo cardiomyopathy induced by dobutamine infusion: a new phenomenon or an old disease with a new name. Echocardiography27(3), pp.E30-E33.
57Arias, A.M., Oberti, P.F., Pizarro, R., Falconi, M.L., de Arenaza, D.P., Zeffiro, S. and Cagide, A.M., 2011. Dobutamine-precipitated Takotsubo cardiomyopathy mimicking acute myocardial infarction: a multimodality image approach. Circulation124(12), pp.e312-e315.
58Chia, P.L. and Lee, E., 2012. Reverse Takotsubo pattern stress cardiomyopathy in a male patient induced during dobutamine stress echocardiography. Annals of the Academy of Medicine, Singapore41(6), pp.264-264.
59D’Aloia, A., Caretta, G., Vizzardi, E., Zanini, G., Bugatti, S., Bonadei, I. and Dei Cas, L., 2012. Heart failure syndrome due to dobutamine stress echocardiography: Tako-Tsubo induced-cardiomiopathy. Panminerva Med54(1), pp.53-5.
60Fineschi, M., D’ascenzi, F., Sirbu, V., Mondillo, S. and Pierli, C., 2013. The Role of Optical Coherence Tomography in Clarifying the Mechanisms for Dobutamine Stress Echocardiography‐Induced Takotsubo Cardiomyopathy. Echocardiography30(5), pp.E121-E124. 10.1111/echo.12107
61Anthony, F.Y., Mitter, S.S. and Chaudhry, H.W., 2013. Apical ballooning syndrome precipitated by dobutamine stress testing. Heart Asia5(1), pp.47-48. DOI: 10.1136/heartasia-2013-010292
62Hajsadeghi, S., Rahbar, M.H., Iranpour, A., Salehi, A., Asadi, O. and Jafarian, S.R., 2018. Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report. Anatolian journal of cardiology19(6), p.412.
63Saito, R., Takahashi, T., Noshita, N., Narisawa, A., Negi, K., Takei, K. and Kaneko, U., 2010. Takotsubo cardiomyopathy induced by dobutamine infusion during hypertensive therapy for symptomatic vasospasm after subarachnoid hemorrhage. Neurologia medico-chirurgica50(5), pp.393-395.
64Abe, Y., Tamura, A. and Kadota, J., 2010. Prolonged cardiogenic shock caused by a high-dose intravenous administration of dopamine in a patient with takotsubo cardiomyopathy. International journal of cardiology141(1), pp.e1-e3.

Dipyridamole, isoprenaline (isoproteranol), terlipressin.

65Koh, AS, Kok, H, Chua, T, Keng, F. Takotsubo cardiomyopathy following dipyridamole pharmacologic stress. Ann Nucl Med. 2010;24(6):497–500.
66Nakao, M, Kawaai, S, Nakamura, D, Tsunoda, A. Takotsubo cardiomyopathy during electrophysiological study with isoproterenol. Int J Cardiol. 2016;223:521–523.
67Di Micoli, A., Buccione, D., Degli Esposti, D., Santi, V., Bastagli, L., Borghi, C., Bernardi, M. and Trevisani, F., 2011. Terlipressin infusion induces Tako-Tsubo syndrome in a cirrhotic man with hepato-renal syndrome. Internal and emergency medicine6(5), pp.437-440. DOI 10.1007/s11739-011-0534-6
68Zdanowicz, J.A., Utz, A.C., Bernasconi, I., Geier, S., Corti, R. and Beinder, E., 2011. “Broken heart” after cesarean delivery. Case report and review of literature. Archives of Gynecology and Obstetrics283(4), pp.687-694.
69Suzuki, T., Nemoto, C., Ikegami, Y., Yokokawa, T., Tsukada, Y., Abe, Y., Shimada, J., Takeishi, Y. and Tase, C., 2014. Development of takotsubo cardiomyopathy with severe pulmonary edema before a cesarean section. Journal of Anesthesia28(1), pp.121-124.
70Crimi, E., Baggish, A., Leffert, L., Pian-Smith, M. C., Januzzi, J. L., & Jiang, Y. (2008). Acute reversible stress-induced cardiomyopathy associated with cesarean delivery under spinal anesthesia. Circulation117(23), 3052-3053.
71Kim, D.H., Bang, D.W. and Park, H.K., 2010. Atypical basal type takotsubo cardiomyopathy: MDCT findings correlated with echocardiography. International Journal of Cardiology141(2), pp.e28-e30.
72Nanayakkara, S. and Cooke, J., 2016, May. Takotsubo cardiomyopathy associated with the administration of intranasal phenylephrine/lignocaine for epistaxis. In International Cardiovascular Forum Journal (Vol. 5).
 73Lee, A. and Nguyen, P., 2016. Takotsubo cardiomyopathy due to systemic absorption of intraocular phenylephrine. Heart, Lung and Circulation25(12), pp.e159-e161.
74Syed, O.N., Heyer, E.J. and Connolly Jr, E.S., 2009. Takotsubo syndrome after carotid endarterectomy. Journal of Neurosurgical Anesthesiology21(2), pp.181-182.

Drugs used in the treatment of mental health conditions
Serotonin norepinephrine reuptake inhibitors (SNRIs)
75Nelson, C. 2017. Serotonin-norepinephrine reuptake inhibitors (SNRIs): Pharmacology, administration, and side effects, UptoDate,viewed 31st March 2019 <>96Goyal, S.K., Gera, C., Singla, M. and 76Kumar, N., 2018. Desvenlafaxine overdose-induced toxic cardiomyopathy and acute left ventricular failure: A case report. Indian Journal of Psychological Medicine40(1), p.99. 10.4103/IJPSYM.IJPSYM_397_17
77Gurunathan, U., 2018. Takotsubo Cardiomyopathy and Intraoperative Cardiac Arrest: Is Desvenlafaxine a Contributing Factor? Journal of Cardiothoracic and Vascular Anesthesia32(1), pp.e16-e18. 10.1053/j.jvca.2017.08.031
78Bergman, B.R., Reynolds, H.R., Skolnick, A.H. and Castillo, D., 2008. A case of apical ballooning cardiomyopathy associated with duloxetine. Annals of internal medicine149(3), pp.218-219.
79Selke, K.J., Dhar, G. and Cohn, J.M., 2011. Takotsubo cardiomyopathy associated with titration of duloxetine. Texas Heart Institute Journal38(5), p.573.
80Rotondi, F., Manganelli, F., Carbone, G. and Stanco, G., 2011. ” Tako-tsubo” cardiomyopathy and duloxetine use. Southern medical journal104(5), pp.345-347. 10.1097/SMJ.0b013e318213f3e5
81Forman, M.B., Sutej, P.G. and Jackson, E.K., 2011. Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use. Texas Heart Institute Journal38(6), p.714.
82Fangio, P., De Jonghe, B., Appéré-De-Vecchi, C., Lachérade, J.C., Terville, J.P., Outin, H. and Dagorn, J., 2007. Acute heart failure associated with venlafaxine poisoning. The American journal of emergency medicine25(2), p.210. 10.1016/j.ajem.2006.08.007
83Christoph, M., Ebner, B., Stolte, D., Ibrahim, K., Kolschmann, S., Strasser, R.H. and Schön, S., 2010. Broken heart syndrome: Tako Tsubo cardiomyopathy associated with an overdose of the serotonin–norepinephrine reuptake inhibitor Venlafaxine. European Neuropsychopharmacology20(8), pp.594-597.
84Daly, M.J., Harbinson, M.T., Dixon, L.J. and Spence, M.S., 2010. An unusual case of mid-ventricular Takotsubo cardiomyopathy. QJM: An International Journal of Medicine103(9), pp.695-696.
85Neil, C.J., Chong, C.R., Nguyen, T.H. and Horowitz, J.D., 2012. Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors. Heart, Lung and Circulation21(4), pp.203-205.
86Vasudev, R., Rampal, U., Patel, H., Patel, K., Bikkina, M. and Shamoon, F., 2016. Selective serotonin–norepinephrine reuptake inhibitors-induced takotsubo cardiomyopathy. North American journal of medical sciences8(7), p.312. 10.4103/1947-2714.187153
87Yamaguchi, H., Nagumo, K., Nakashima, T., Kinugawa, Y. and Kumaki, S., 2014. Life-threatening QT prolongation in a boy with attention-deficit/hyperactivity disorder on atomoxetine. European journal of pediatrics173(12), pp.1631-1634.
88Naguy, A., Al-Mutairi, H. and Al-Tajali, A., 2016. Atomoxetine-related Takotsubo cardiomyopathy. Journal of Psychiatric Practice®22(3), pp.232-233.
89De Roock, S., Beauloye, C., De Bauwer, I., Vancraynest, D., Gurne, O., Gerber, B. and Hantson, P., 2008. Tako-tsubo syndrome following nortriptyline overdose. Clinical Toxicology46(5), pp.475-478.
90Kitami, M, Oizumi, H, Kish, SJ, Furukawa, Y. Takotsubo cardiomyopathy associated with lithium intoxication in bipolar disorder: a case report. J Clin Psychopharmacol. 2014;34(3):410–411.
91Narayanan, M.A., Haddad, T.M., Bansal, O., Baskaran, J., Azzouz, M.S., Akinapelli, A. and Esterbrooks, D.J., 2015. Acute cardiomyopathy precipitated by lithium: is there a direct toxic effect on cardiac myocytes?. The American Journal of Emergency Medicine33(9), pp.1330-e1.

Drugs used in the treatment of cancer

Chemotherapy agents

92Desai, R., Abbas, S.A., Goyal, H., Durairaj, A., Fong, H.K., Hung, O., Sachdeva, R., Barac, A., Yusuf, S.W. and Kumar, G., 2019. Frequency of takotsubo cardiomyopathy in adult patients receiving chemotherapy (from a 5-year nationwide inpatient study). The American Journal of Cardiology123(4), pp.667-673.
93Balanescu, D.V., Liu, V.Y., Donisan, T., Agha, A.M., Lopez-Mattei, J.C., Giza, D.E., Iliescu, G.D., Palaskas, N., Kim, P.Y., Boone, D.L. and Yang, E.H., 2018. P1253 Clinical features and outcomes of patients with chemotherapy-induced Takotsubo stress cardiomyopathy. European Heart Journal39(suppl_1), pp.ehy565-P1253.https://doi-org/10.1093/eurheartj/ehy565.P1253
94Sattler, K., El-Battrawy, I., Lang, S., Zhou, X., Schramm, K., Tülümen, E., Kronbach, F., Röger, S., Behnes, M., Kuschyk, J. and Borggrefe, M., 2017. Prevalence of cancer in Takotsubo cardiomyopathy: short and long-term outcome. International journal of cardiology238, pp.159-165.
95Akhtar, S.S., Salim, K.P. and Bano, Z.A., 1993. Symptomatic cardiotoxicity with high-dose 5-fluorouracil infusion: a prospective study. Oncology50(6), pp.441-444.
96Gianni, M., Dentali, F. and Lonn, E., 2009. 5 flourouracil-induced apical ballooning syndrome: a case report. Blood Coagulation & Fibrinolysis20(4), pp.306-308.
97Kobayashi, N., Hata, N., Yokoyama, S., Shinada, T., Shirakabe, A. and Mizuno, K., 2009. A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma. Journal of Nippon Medical School76(1), pp.27-33.
98Stewart, T., Pavlakis, N. and Ward, M., 2010. Cardiotoxicity with 5‐fluorouracil and capecitabine: more than just vasospastic angina. Internal medicine journal40(4), pp.303-307.
99Basselin, C., Fontanges, T., Descotes, J., Chevalier, P., Bui‐Xuan, B., Feinard, G. and Timour, Q., 2011. 5‐Fluorouracil—Induced Tako‐Tsubo—Like Syndrome. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy31(2), pp.226-226.
100Grunwald, M.R., Howie, L. and Diaz Jr, L.A., 2011. Takotsubo cardiomyopathy and fluorouracil: case report and review of the literature. Journal of Clinical Oncology30(2), pp.e11-e14.
101Radhakrishnan, V, Bakhshi, S. 5-Fluorouracil-induced acute dilated cardiomyopathy in a pediatric patient. J Pediatr Hematol Oncol. 2011;33(4):323.
102Çalık, A.N., Çeliker, E., Velibey, Y., Çağdaş, M. and Güzelburç, Ö., 2012. Initial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditis. The American journal of emergency medicine30(1), pp.257-e1.
103Lim, S.H.S., Wilson, S.M., Hunter, A., Hill, J. and Beale, P., 2013. Takotsubo cardiomyopathy and 5-fluorouracil: getting to the heart of the matter. Case reports in oncological medicine2013.
104Ozturk, M.A., Ozveren, O., Cinar, V., Erdik, B. and Oyan, B., 2013. Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction. Blood Coagulation & Fibrinolysis24(1), pp.90-94.
105Goel, S., Sharma, A., Garg, A., Chandra, A. and Shetty, V., 2014. Chemotherapy induced Takotsubo cardiomyopathy. World Journal of Clinical Cases: WJCC2(10), p.565.
106Knott, K., Starling, N., Rasheed, S., Foran, J., Cafferkey, C., Rosen, S., Nicholson, A., Baksi, J. and Lyon, A., 2014. A case of Takotsubo syndrome following 5-fluorouracil chemotherapy. International journal of cardiology177(2), pp.e65-e67.
107Singh, S.B. and Harle, I.A., 2014. Takotsubo cardiomyopathy secondary in part to cancer-related pain crisis: a case report. Journal of pain and symptom management48(1), pp.137-142.
108Abdelrahman, M., McCarthy, M.T., Yusof, H. and Osman, N., 2016. Successful capecitabine rechallenge following 5-fluorouracil-induced Takotsubo syndrome. Oxford medical case reports2016(3), pp.47-50.
109De Pasquale, M.D., Mastronuzzi, A., De Sio, L., Serra, A., Grimaldi, C., Chinali, M. and Giordano, U., 2016. Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma. BMC pediatrics16(1), p.99.
110Fakhri, Y., Dalsgaard, M., Nielsen, D. and Madsen, P.L., 2016. 5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI. BMJ case reports2016, p.bcr2015213783.
111Saif, M.W., Smith, M. and Maloney, A., 2016. The first case of severe takotsubo cardiomyopathy associated with 5-fluorouracil in a patient with abnormalities of both dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS) genes. Cureus8(9)..
112Coen, M., Rigamonti, F., Roth, A. and Koessler, T., 2017. Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature. BMC cancer17(1), p.394.
113Shekar, C. and Tigadi, S., 2018. 5-flurouracil induced takotsubo cardiomyopathy. Journal of the American College of Cardiology71(11 Supplement), p.A2431.
114Stewart, T., Pavlakis, N. and Ward, M., 2010. Cardiotoxicity with 5‐fluorouracil and capecitabine: more than just vasospastic angina. Internal medicine journal40(4), pp.303-307.
115Endo, A., Yoshida, Y., Nakashima, R., Takahashi, N. and Tanabe, K., 2013. Capecitabine induces both cardiomyopathy and multifocal cerebral leukoencephalopathy. International heart journal54(6), pp.417-420.
116Y-Hassan, S, Tornvall, P, Tornerud, M, Henareh, L. Capecitabine caused cardiogenic shock through induction of global takotsubo syndrome. Cardiovasc Revasc Med. 2013;14(1):57–61.
117Fontanella, C., Aita, M., Cinausero, M., Aprile, G., Baldin, M.G., Dusi, V., Lestuzzi, C., Fasola, G. and Puglisi, F., 2014. Capecitabine-induced cardiotoxicity: more evidence or clinical approaches to protect the patients’ heart?. OncoTargets and therapy7, p.1783.
118Klag, T., Cantara, G., Ong, P., Kaufmann, M., Sechtem, U. and Athanasiadis, A., 2014. Epicardial coronary artery spasm as cause of capecitabine-induced tako tsubo cardiomyopathy. Clinical Research in Cardiology103(3), pp.247-250.
119Qasem, A., Abdulhak, A.A.B., Aly, A. and Moormeier, J., 2016. Capecitabine-induced takotsubo cardiomyopathy: a case report and literature review. American journal of therapeutics23(5), pp.e1188-e1192.
120Sakamoto, T., Endo, A., Ito, S., Okada, T., Watanabe, N. and Tanabe, K., 2016. Capecitabine Induced Takotsubo Cardiomyopathy. Journal of Cardiac Failure22(9), p.S220
121Coen, M., Rigamonti, F., Roth, A. and Koessler, T., 2017. Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature. BMC cancer17(1), p.394.
122Budnik, M., Kucharz, J., Wiechno, P., Demkow, T., Kochanowski, J., Górska, E. and Opolski, G., 2018. Chemotherapy-induced Takotsubo syndrome. Clinical Pulmonary Research, pp.19-29.
123Sabharwal, S., Sharma, A., Manek, G. and Grover, P., 2018. A case of capecitabine-induced takotsubo cardiomyopathy. Chest154(4).
124Franco, T.H., Khan, A., Joshi, V. and Thomas, B., 2008. Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Therapeutics and clinical risk management4(6), p.1367.
125 Kim, L., Karas, M. and Wong, S.C., 2008. Chemotherapy-induced takotsubo cardiomyopathy. The Journal of invasive cardiology20(12), pp.E338-40.
126Geisler, B.P., Raad, R.A., Esaian, D., Sharon, E. and Schwartz, D.R., 2015. Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome. Journal for immunotherapy of cancer3(1), p.4.
127Ng, K.H., Dearden, C. and Gruber, P., 2015. Rituximab-induced Takotsubo syndrome: more cardiotoxic than it appears?. BMJ case reports2015, p.bcr2014208203.
128Khanji, M, Nolan, S, Gwynne, S, Pudney, D, Ionescu, A. Tako-Tsubo syndrome after trastuzumab—an unusual complication of chemotherapy for breast cancer. Clin Oncol (R Coll Radiol). 2013;25(5):329.
129Aguiar-Ricardo, I., Nunes-Ferreira, A., Roda, Â. and Bras-Rosario, L., 2019. Omalizumab induced Takotsubo syndrome: case report. European Heart Journal-Case Reports3(1), p.yty155.
130Ovadia, D., Esquenazi, Y., Bucay, M. and Bachier, C.R., 2014. Association between takotsubo cardiomyopathy and axitinib: case report and review of the literature. Journal of Clinical Oncology33(1), pp.e1-e3.
131White, A.J., LaGerche, A., Toner, G.C. and Whitbourn, R.J., 2009. Apical ballooning syndrome during treatment with a vascular endothelial growth factor receptor antagonist. International journal of cardiology131(3), pp.e92-e94. (pazopanib)
132Numico, G., Sicuro, M., Silvestris, N., Mozzicafreddo, A., Trogu, A., Malossi, A., Cristofano, A. and Thiebat, B., 2012. Takotsubo syndrome in a patient treated with sunitinib for renal cancer. Journal of Clinical Oncology30(24), pp.e218-e220.
133Cevallos, J. and Lyon, A., 2018. Takotsubo Syndrome and Cancer. In Cancer and Cardiovascular Disease (pp. 45-54). Springer, Cham.
134Bhakta, S, Flick, SM, Cooney, MM. Myocardial stunning following combined modality combretastatin-based chemotherapy: two case reports and review of the literature. Clin Cardiol. 2009;32(12):80–84.
135 Khakoo, A.Y., Halushka, M.K., Rame, J.E., Rodriguez, E.R., Kasper, E.K. and Judge, D.P., 2005. Reversible cardiomyopathy caused by administration of interferon α. Nature Reviews Cardiology2(1), p.53.
136Damodaran, S., Mrozek, E., Liebner, D. and Kendra, K., 2014. Focal takotsubo cardiomyopathy with high-dose interleukin-2 therapy for malignant melanoma. Journal of the National Comprehensive Cancer Network12(12), pp.1666-1670.
137Coli, S., Pigazzani, F. and Gaibazzi, N., 2015. Midventricular Takotsubo cardiomyopathy after oxaliplatin infusion: an unreported side effect. Journal of Cardiovascular Medicine16(9), pp.646-649.
138 Sundaravel, S., Alrifai, A., Kabach, M. and Ghumman, W., 2017. FOLFOX induced takotsubo cardiomyopathy treated with impella assist device. Case reports in cardiology2017.
139Baumann, S., Huseynov, A., Goranova, D., Faust, M., Behnes, M., Nolte, F., Heidenreich, D., Hofmann, W.K., Borggrefe, M., Akin, I. and Klein, S., 2014. Takotsubo cardiomyopathy after systemic consolidation therapy with high-dose intravenous cytarabine in a patient with acute myeloid leukemia. Oncology research and treatment37(9), pp.487-490.
140Goel, S., Sharma, A., Garg, A., Chandra, A. and Shetty, V., 2014. Chemotherapy induced Takotsubo cardiomyopathy. World Journal of Clinical Cases: WJCC2(10), p.565.
141 Malley, T. and Watson, E., 2016. A case of takotsubo cardiomyopathy after chemotherapy. Oxford medical case reports2016(4), pp.55-58.

Drugs used in obstetrics

142Jeon, J.H., Her, S.H., Lee, J.M., Yoon, H.J., Chin, J.Y., Park, K.H., Won, K.Y., Jie, B.S., Park, Y.R. and Jin, S.W., 2007. A case of stress-induced cardiomyopathy related with the postpartum period. Korean Circulation Journal37(8), pp.388-392.
143Citro, R., Pascotto, M., Provenza, G., Gregorio, G. and Bossone, E., 2010. Transient left ventricular ballooning (tako-tsubo cardiomyopathy) soon after intravenous ergonovine injection following caesarean delivery. International Journal of Cardiology138(2), pp.e31-34-34.
144Kim, S.Y., Yoon, J.H. and Lee, S.H., 2011. Takotsubo-like severe left ventricular dysfunction after cesarean delivery in a 28-year old woman. Korean Circulation Journal41(2), pp.101-104.
145Keskin, A., Winkler, R., Mark, B., Kilkowski, A., Bauer, T., Koeth, O., Camci, S., Cornelius, B., Layer, G., Zeymer, U. and Zahn, R., 2010. Tako-tsubo cardiomyopathy after administration of ergometrine following elective caesarean delivery: a case report. Journal of Medical Case Reports4(1), p.280.
146Vital, M., Lebert, C., Reignier, J. and Ducarme, G., 2013. Peripartum cardiomyopathy vs. sulprostone-associated heart failure? A case report and analysis of the literature. Archives of Gynecology and Obstetrics288(6), pp.1423-1424.
147Suzuki, T., Nemoto, C., Ikegami, Y., Yokokawa, T., Tsukada, Y., Abe, Y., Shimada, J., Takeishi, Y. and Tase, C., 2014. Development of takotsubo cardiomyopathy with severe pulmonary edema before a cesarean section. Journal of Anesthesia28(1), pp.121-124.
148Courand, P.Y., Jenck, S., Cassar, E., David, E., Carrabin, N. and Lantelme, P., 2012. Tako-tsubo cardiomyopathy probably associated with administration of sulprostone following cesarean delivery. Revista Española de Cardiología65(08), pp.770-771.
149Sato, A., Yagihara, N., Kodama, M., Mitsuma, W., Tachikawa, H., Ito, M., Hanawa, H. and Aizawa, Y., 2011. Takotsubo cardiomyopathy after delivery in an oestrogen-deficient patient. International journal of cardiology149(2), pp.e78-e79.
150Petta R, Zullo F, Tipaldi A, Guida M. 2013. A “Broken heart” syndrome case after cesarean delivery. prevention and risk assessment. Translational Medicine@ UniSa; 7:29.
151Besnier E, Hubscher C, Doguet F, Bessou JP, Dureuil B. Extracorporeal membrane oxygenation support for tako-tsubo syndrome after urgent caesarean section. Ann Fr Anesth Reanim 2013; 32:704-6.
152D’Amato, N., Colonna, P., Brindicci, P., Campagna, M.G., Petrillo, C., Cafarelli, A. and D’Agostino, C., 2008. Tako-Tsubo syndrome in a pregnant woman. European Journal of Echocardiography9(5), pp.700-703.
153Bortnik M, Verdoia M, Schaffer A, Occhetta E, Marino P. Ventricular fibrillation as primary presentation of takotsubo cardiomyopathy after complicated cesarean delivery. World Journal of Cardiology 2012; 4:214.
154Freitas, H.F.G., Renault, R., Ribeiro, E.S., Andrade, F.M., Brito Jr, F.S. and Velloso, L.G., 2011. Sudden cardiac arrest due to puerperal transient left ventricular apical ballooning syndrome. International journal of cardiology149(1), pp.e12-e13.
155Kraft, K., Graf, M., Karch, M. and Felberbaum, R., 2017. Takotsubo syndrome after cardiopulmonary resuscitation during emergency cesarean delivery. Obstetrics & Gynecology, 129(3), pp.521-524.
156Lee, N., Lee, K., Banta, J., D’Ambrosio, M., Hannallah, B., Benz, M. and Voudouris, A., 2017. Takotsubo Cardiomyopathy-Associated Ventricular Standstill in a Peripartum Patient. Journal of Molecular and Cellular Cardiology112, p.139.
157Kucia, A.M., Dekker, G. and Arstall, M., 2015. Peripartum takotsubo cardiomyopathy. Journal of the American College of Cardiology65(10 Supplement), p.A926.
158Bhaskar S, Shevlin M, Koumousidis A, Hunter A. 2013. Broken heart syndrome in a new mother with HELLP syndrome: A case report. OA Case Reports, 2(8):71.
159Jeong, H., Lee, S., Jeong, C., Lee, J., Jeong, S., Chung, S. and Yoo, K., 2011. Inverted takotsubo-like left ventricular dysfunction with pulmonary oedema developed after caesarean delivery complicated by massive haemorrhage in a severe preeclamptic parturient with a prolonged painful labour. Case Reports in Anesthesiology2011.
160 Crimi, E., Baggish, A., Leffert, L., Pian-Smith, M.C., Januzzi, J.L. and Jiang, Y., 2008. Acute reversible stress-induced cardiomyopathy associated with cesarean delivery under spinal anesthesia. Circulation117(23), pp.3052-3053.
161Gnanavelu, G., Sathiakumar, D.B.D., Narasimhan, M.K. and Priya, M.S., 2014. Stress-induced cardiomyopathy following cesarean delivery under general anesthesia. The Journal of Obstetrics and Gynecology of India64(1), pp.19-21.
162Ozpelit, E, Ozpelit, ME, Akdeniz, B, Goldeli, O. 2016. Ergotamine-induced takotsubo cardiomyopathy. Am J Ther, 23(2):597–600.
163Minatoguchi, M., Itakura, A., Takagi, E., Nishibayashi, M., Kikuchi, M. and Ishihara, O., 2014. Takotsubo cardiomyopathy after cesarean: A case report and published work review of pregnancy‐related cases. Journal of Obstetrics and Gynaecology Research40(6), pp.1534-1539.
164Lee, J. Y., Kwon, H. J., Park, S. W., & Lee, Y. M. (2017). Acute pulmonary edema caused by takotsubo cardiomyopathy in a pregnant woman undergoing transvaginal cervical cerclage: A case report. Medicine96(1).
165Shoji, T., Takatori, E., Oyama, R., Kumagai, S., Fukushima, A., Yoshizaki, A. and Sugiyama, T., 2012. Tako-Tsubo cardiomyopathy caused immediately following cesarean section delivery of triplets: a case report. Gynecologic and obstetric investigation74(1), pp.84-88.
166Niki, Y., Takasu, A., Sakakibara, K., Matsuzaki, Y., Tsuboi, H. and Minakuchi, K., 2003. A case report of postpartum pulmonary edema associated with long-term administration of ritodrine. Journal of the Japanese Society of Intensive Care Medicine10(3), pp.201-205

Asthma medications

167Stanojevic, D.A., Alla, V.M., Lynch, J.D. and Hunter, C.B., 2010. Case of reverse takotsubo cardiomyopathy in status asthmaticus. Southern Medical Journal103(9), p.964.
168Salahuddin, F.F., Sloane, P., Buescher, P., Agarunov, L. and Sreeramoju, D., 2013. A case of apical ballooning syndrome in a male with status asthmaticus; highlighting the role of B2 agonists in the pathophysiology of a reversible cardiomyopathy. Journal of Community Hospital Internal Medicine Perspectives3(2), p.20530.
169Patel, B., Assad, D., Wiemann, C. and Zughaib, M., 2014. Repeated use of albuterol inhaler as a potential cause of Takotsubo cardiomyopathy. The American Journal of Case Reports15, p.221.
170Marmoush, F.Y., Barbour, M.F., Noonan, T.E. and Al-Qadi, M.O., 2015. Takotsubo cardiomyopathy: a new perspective in Asthma. Case Reports in Cardiology2015.
171Sharrett, J, Surabhi, S, Philips, S, Morse, H. Fatal case of recurrent takotsubo cardiomyopathy presenting with cardiac arrest and variable ventricular involvement what role beta agonist and beta blockers? J S C Med Assoc. 2015;111(4):127–130.
172Kamath, A.P., Shenoy, M., Kulandaisamy, S., Seneviratne, C., Kupfer, Y. and Chandar, P., 2016. Takotsubo Cardiomyopathy Associated With High Dose Albuterol, ATS Journals. Viewed online 11th April 2019,
173Parsa, S.A., Khaheshi, I., Memaryan, M. and Naderian, M., 2016. Takotsubo cardiomyopathy following recurrent doses of albuterol due to asthma attack: a very rare case report. Future Cardiology12(6), pp.609-612.
174Mendoza, I. and Novaro, G.M., 2012. Repeat recurrence of takotsubo cardiomyopathy related to inhaled beta-2-adrenoceptor agonists. World Journal of Cardiology4(6), p.211.
175Venditti, F, Bellandi, B, Parodi, G. Fatal Tako-Tsubo cardiomyopathy recurrence after β2-agonist administration. Int J Cardiol. 2012;161(1):10–11.
176Melao, F, Nunes, JP, Vasconcelos, M. Stress-induced cardiomyopathy associated with ipratropium bromide therapy in a patient with chronic obstructive pulmonary disease. Rev Port Cardiol. 2014;33(3):171–174.
177Dakkak, M., 2016. Seizure, theophylline toxicity and Takotsubo cardiomyopathy (first report): case report. Reactions1583, pp.1052-9.
178Khwaja, Y.H. and Tai, J.M., 2016. Takotsubo cardiomyopathy with use of salbutamol nebulisation and aminophylline infusion in a patient with acute asthma exacerbation. BMJ Case Reports2016, p.bcr2016217364.
179Saeki, S., Matsuse, H., Nakata, H., Fukahori, S., Miyahara, Y. and Kohno, S., 2006. Case of bronchial asthma complicated with Takotsubo cardiomyopathy after frequent epinephrine medication. Nihon Kokyuki Gakkai zasshi= The Journal of the Japanese Respiratory Society44(10), pp.701-705.

Illicit drugs

180Chokshi, SK, Moore, R, Pandian, NG, Isner, JM. 1989. Reversible cardiomyopathy associated with cocaine intoxication. Ann Intern Med, 111(12):1039–1040.
181Arora, S, Alfayoumi, F, Srinivasan, V. 2006. Transient left ventricular apical ballooning after cocaine use: is catecholamine cardiotoxicity the pathologic link? Mayo Clin Proc, 81(6):829–832.
182Daka, MA, Khan, RS, Deppert, EJ. 2007. Transient left ventricular apical ballooning after a cocaine binge. J Invasive Cardiol, 19(12):378–380.
Butterfield, M, Riguzzi, C, Frenkel, O, Nagdev, A. 2015. Stimulant-related takotsubo cardiomyopathy. Am J Emerg Med, 33(3):1–3.
183Sarkar, S, Arguelles, E, de Elia, C. 2013. Takotsubo cardiomyopathy presenting as a non-ST segment elevation myocardial infarction in the setting of cocaine use and asthma exacerbation. Int J Cardiol, 168(1):1–2.
184Srikanth, S, Barua, R, Ambrose, J. Methamphetamine-associated acute left ventricular dysfunction: a variant of stress-induced cardiomyopathy. Cardiology. 2008;109(3):188–192.
185Fulcher, J, Wilcox, I. Basal stress cardiomyopathy induced by exogenous catecholamines in younger adults. Int J Cardiol. 2013;168(6):158–160.
186Al-Abri, S, Meier, KH, Colby, JM, Smollin, CG, Benowitz, NL. Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. Clin Toxicol (Phila). 2014;52(10):1292–1295.
187Alliu, S., Adejumo, A., Adegbala, O., Namana, V., Chetana, P., Yevgeniya, B., Hecht, M., Wolf, L., Kamholz, S., Hollander, G. and Shani, J., 2017. Association Between Cannabis Use and TakoTsubo Cardiomyopathy (TTC): Analysis from the NIS 2012-2014. Circulation Research, 121(suppl_1), pp.A209-A209.
188Khalid, S., Khalid, A. and Maroo, P., 2018. Risk Factors and Management of Takotsubo Cardiomyopathy. Cureus, 10(5): e2626.


Withdrawal syndromes

189Suzuki, K, Osada, N, Akasi, YJ. 2004. An atypical case of “Takotsubo cardiomyopathy” during alcohol withdrawal: abnormality in the transient left ventricular wall motion and a remarkable elevation in the ST segment. Intern Med, 43(4):300–305.
190Alexandre, J, Benouda, L, Champ-Rigot, L, Labombarda, F. 2011. Takotsubo cardiomyopathy triggered by alcohol withdrawal. Drug Alcohol Rev, 30(4):434–437.
191Stout, B.J., Hoshide, R. and Vincent, D.S., 2012. Takotsubo cardiomyopathy in the setting of acute alcohol withdrawal. Hawai’i Journal of Medicine & Public Health71(7), p.193.
192Lemesle, F, Lemesle, F, Nicola, W, Pierre Jonville-Bera, A. 2010. First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction. Am J Emerg Med, 28(3):385–386.
193Saiful, FB, Lafferty, J, Jun, CH. 2011. Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal. Rev Cardiovasc Med, 12(3):164–167.
194Rivera, JM, Locketz, AJ, Fritz, KD. “Broken heart syndrome” after separation (from OxyContin). Mayo Clinic Proceedings. 2006;81(6):825–828.
195Sarcon, A, Ghadri, JR, Wong, G, Luscher, TF, Templin, C, Amsterdam, E. Takotsubo cardiomyopathy associated with opiate withdrawal. QJM. 2014;107(4):301–302.
196Pizon, AF, Lovecchio, F. Reversible cardiomyopathy complicating intrathecal baclofen withdrawal: a case report. J Med Toxicol. 2007;3(4):187–189.
197Kireyev, D, Poh, KK. Reversible electrocardiogram changes and cardiomyopathy secondary to baclofen withdrawal syndrome. Am Heart Hosp J. 2010;8(1):52–54.
198Maruyama, S, Nomura, Y, Fukushige, T. 2006. Suspected takotsubo cardiomyopathy caused by withdrawal of buprenorphine in a child. Circ J, 70(4):509–511.
199Jefic, D, Koul, D, Boguszewski, A, Martini, W. Transient left ventricular apical ballooning syndrome caused by abrupt metoprolol withdrawal. Int J Cardiol. 2008;131(1):35–37.
200Tomcsanyi, J, Javor, K, Arabadzisz, H, Zsoldos, A, Wagner, V, Sarman, B. Takotsubo cardiomyopathy: a novel beta-adrenergic blocker withdrawal syndrome. Orv Hetil. 2013;154(7):267–271.

Other drugs

201Dziewierz, A, Olszanecka, A, Wilinski, J. Inverted takotsubo cardiomyopathy in a patient with essential thrombocythemia exposed to anagrelide and phentermine. Int J Cardiol. 2012;160(2):31–32.
202Proietti, R., Rognoni, A., Ardizzone, F., Maccio, S., Santagostino, A. and Rognoni, G., 2009. Atypical Takotsubo syndrome during anagrelide therapy. Journal of Cardiovascular Medicine10(7), pp.546-549.
203Sandhu, G, Servetnyk, Z, Croitor, S, Herzog, E. Atropine aggravates signs and symptoms of takotsubocardiomyopathy. Am J Emerg Med. 2010;28(2):255–257.
204Y-Hassan, S, Jernberg, T. Bromocriptine-induced coronary spasm caused acute coronary syndrome, which triggered its own clinical twin—takotsubo syndrome. Cardiology. 2011;119(1):1–6.
205McAllister, R.K., 2014, April. Stress-induced (takotsubo) cardiomyopathy following thoracic epidural steroid injection for postherpetic neuralgia. In Baylor University Medical Center Proceedings (Vol. 27, No. 2, pp. 120-121). Taylor & Francis.
206 Schussler, J.M., 2014. Takotsubo cardiomyopathy following epidural steroid injection: yet another way to break the heart. Proceedings (Baylor University. Medical Center)27(2), p.122.
207Baldacci, F., Vergallo, A., Del Dotto, P., Ulivi, M., Palombo, C., Casolo, G., Tomei, G. and Bonuccelli, U., 2014. Occurrence of Takotsubo syndrome in a patient with Parkinson’s disease after entacapone add-on. Parkinsonism & related disorders20(11), pp.1313-1314.
208Gabriel, L., Chenu, P., Guédès, A., Dangoisse, V., Marchandise, B., Blommaert, D., Jamart, J., De Roy, L. and Schroeder, E., 2011. A possible association between takotsubo cardiomyopathy and treatment with flecainide. International journal of cardiology147(1), pp.173-175.
209Santoro, F., Ieva, R., Ferraretti, A., Carpagnano, G., Pappalardo, I., De Gennaro, L., Di Biase, M. and Brunetti, N.D., 2013. Tako-tsubo cardiomyopathy after influenza vaccination. International journal of cardiology167(2), pp.e51-e52.
210Kwon, S.A., Yang, J.H., Kim, M.K., Park, S.W., Kim, S.H., Park, K.H. and Park, W.J., 2010. A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. International journal of cardiology145(3), pp.e111-e113.
211Eliades, M., El-Maouche, D., Choudhary, C., Zinsmeister, B. and Burman, K.D., 2014. Takotsubo cardiomyopathy associated with thyrotoxicosis: a case report and review of the literature. Thyroid24(2), pp.383-389.
212Balsa, A.M., Ferreira, A.R., Alves, M. and Guimarães, J., 2017. Takotsubo cardiomyopathy associated with levothyroxine over-replacement. European endocrinology13(1), p.30.
213Maricic, L., Makarovic, S., Selthofer-Relatic, K., Jelic, K. and Steiner, R., 2015. Takotsubo cardiomyopathy caused iatrogenic thyrotoxicosis. Case Reports in Internal Medicine2(2), pp.82-84. 230
214Sacco, A, Morici, N, Belli, O, Bossi, I, Mafrici, A, Klugmann, S. Tako-Tsubo like syndrome triggered by meperidine. Med J Malaysia. 2011;66(5):520–521.
215Ramanath, VS, Andrus, BW, Szot, CR, Kaplan, AV, Robb, JF. Takotsubo cardiomyopathy after midodrine therapy. Tex Heart Inst J. 2012;39(1):158–159.
216Placci, A., Sella, G., Bellanti, G. and Margheri, M., 2015. Anabolic androgenic steroid-induced Takotsubo cardiomyopathy. BMJ case reports2015, p.bcr2014209089.
217Rojas-Marte, G., John, J., Sadiq, A., Moskovits, N., Saunders, P. and Shani, J., 2015. Medication-induced Takotsubo Cardiomyopathy presenting with cardiogenic shock—utility of extracorporeal membrane oxygenation (ECMO): case report and review of the literature. Cardiovascular Revascularization Medicine16(1), pp.47-51.
218Kocaoglu, I., Gökaslan, S., Karagöz, A., Sahin, D., Ucar, Ö. and Aydogdu, S., 2012. Zolmitriptan-induced acute myocardial infarction. Cardiology journal19(1), pp.76-78.
219Garg, J, Aronow, WS, Devabhaktuni, S, Ahmad, H. Takotsubo syndrome (or apical ballooning syndrome) secondary to zolmitriptan. Am J Ther. 2015;22(2):52–56.